A CMOS image sensor and a method of fabricating the same. Catheters are provided that can be advanced over single length guide wires and which can be retracted over single length wire shafts of distal embolic protection devices. Individual items of content are then clustered using a clustering algorithm, and a distance matrix from the probability distribution is built. An MDC provides a single mechanism for interacting with subscribers of multiple carriers, regardless of each carrier’s underlying infrastructure. The closure and the adjacent fixed member are normally locked together by a slider element which engages a keeper element when the closure is in its closed position.