The present invention provides dyes, reactive dyes and labeled reagents that may be used in the detection or quantification of desirable target molecules, such as proteins and nucleic acids. The apparatus contains a signal processor, integral ear probe, and remote ear, and scalp probes all packaged as a single handheld battery operated device. The data voltage is applied for a longer period of time than the compensation voltage, but the magnitude of the compensation voltage is greater than the magnitude of the data voltage. An electrical connector can extend from a bond pad on the top semiconductor die to a redistribution circuit on the semiconductor die below. The method may finally include performing a security action in response to determining that the application contains malware.