A compound having the general structure shown in Formula 1:or pharmaceutically acceptable salts andor solvates thereof are useful in treating diseases or conditions mediated by NK1 receptors, for example various physiological disorders, symptoms or diseases, including emesis, depression, anxiety and cough. A timing adjustment circuit generates a first clock supplied to a ramp generator and a second clock supplied to a counter so that a phase difference between the first clock and the second clock is within a predetermined range and differs according to lines in an image sensor. The low-heat accumulating thermoplastic resin composition of the present invention is capable of providing a dark-colored molded product exhibiting a less heat accumulation as well as excellent weather resistance and impact resistance. Permission to use a slot to communicate between any two nodes is dynamically adjusted by the channel access protocol, which locally: estimates load to neighboring nodes; allocates or deallocates slot usage to adapt to load and avoid interference; and asserts and advertises slot usage within an interference area about itself. Upon the reception of an image forming signal at the image forming apparatus, the first and the second developer carrying members are rotated before the first latent image on the image bearing member is developed.