Various embodiments of the present invention provide systems and methods for adaptive channel bit density estimation. A statistical correlation analysis is performed to determine which of the temperature sensors experiencing changes in temperature are most linearly related to changes in the linear position of the first machine member relative to the second machine member and an \u201ceffective\u201d coefficient of thermal expansion is thereafter determined as the rate of change of position, i. butoxycarbonyl or benzoyl; PMP is p-methoxyphenyl group in the presence of a condensation agent and an activating agent to obtain C-13 esters of formula 3;c) treating the coupled products 3 with weak acidic medium to open the oxazolidine ring to obtain intermediates of formula 4; wherein R is a tert. The member may extend across the left ventricular cavity or between points spaced apart around the left ventricular cavity. Also, methods of treating bacterial infection, pharmaceutical compositions, molecular complexes and processes for preparing compounds.