A therapy whereby high frequency electromagnetic pulses are externally applied to a head. The method includes introducing a semiconductor substrate into a process chamber. The system provides retailer control at a single store level, regional or national level of inventory, distribution and destruction of digital media, such as music, movies, video games, computer software, ring tones for cell phones, etc. In some embodiments, the value of the award is based on a condition associated with the message, publication of the message, etc. Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate from ingenol and to methods of producing said intermediates. The polishing operation location is displaced across the surface of the substrate from said second location of the substrate toward said first location of the substrate.