The present invention provides an ultrasound-mediated drug delivery method for administering a compound to a targeted tissue, and the method at least comprises the following steps: First, an ultrasound apparatus is provided. Sidewalls and radially outermost portions of the opening base are lined with masking material. The voltage generation circuits produce a potential difference between the bit lines and the source lines in response to an instruction to transition from standby state to active state. An optional protective layer may be deposited on top of the microporous ink-receptive layer.