A continuous extrusion machine has a chassis supporting a wheel for rotation by a motor. The IC includes a parasitic diode coupled between a first voltage source and a second voltage source. The oil outlet chamber is delimited by a third seal between the bearing housing and the shaft, and a gas discharge chamber is arranged between the third seal and the rotating wheel-side seal. The present inventors revealed that BLT2 has an important role in metastasis of cancer cells and angiogenesis of tumor and demonstrated that the anti-cancer activity of the BLT2 inhibitors is accomplished by inducing the apoptosis of cancer cells, inhibiting the metastasis of cancer cells, or inhibiting the angiogenesis of tumor.