Devices and methods provide accurate targeting, placement, andor stabilization of an electrode or other instrument into the brain or other body organ, such as to treat severe tremor or other neurological disorders. The printing press folder includes a cutting apparatus cutting a moving web to form successive signatures, a first acceleration cylinder and a second acceleration cylinder. The receiving member defines two sliding grooves. The first diameter is smaller than the second diameter, and a distance between center points of adjoining the weld dots is greater than the second diameter of either of the adjoining weld dots. The fiberscope incorporates spectral filter optical elements that provide environmental insensitivity, particularly to temperature and moisture. The device may be a substance delivery device that is configured to deliver a substance into the subgerminal cavity of the egg.