A method is provided for bonding substrates using a homogeneous fluid and a polymerizing condition. despite its high molecular weight to be substantially colorless after the molding process. Each pin comprises a load cell operable to transmit measurement signals, and a height adjuster operable to receive adjustment signals and execute pin height adjustments upon receiving adjustment signals. The phage library produced was used to screen for polypeptides having brain-localized activity, which yielded such several polypeptides.