The present disclosure relates to compounds effective as human protein tyrosine phosphatase beta inhibitors thereby regulating angiogenesis. The substrate has a feature that can be stably realizable and having a simple structure and that a light waveguide formed on the substrate surface or an optical element formed thereon can be connected without core alignment to an optical element provided on the optical fiber of the optical fiber connector to be connected to the optical fiber connecting end member. The planar web, side flanges and bottom flanges are all integrally formed from a single member. The distribution means is controlled by a first clock signal. Preferably, the controlling lever is formed with a stop or protrusion at the lower edge thereof for self-keeping in the braked position for parking the wheeled walker. A TNF-\u03b1 inhibiting agent includes at least one of Lenalinomide; Thalidomide; L-Carnosine; Infliximab; Etanercept; a stem cell preparation; derivatives thereof, isomers thereof, or pharmaceutically acceptable salts thereof.