The invention provides derivatives of thiazolo4,5-d1pyrimidine and their use as inhibitors of proinflammatory cytokines. The perforation line is slit at least one end for a first predetermined distance to aid in tearing the bag from the roll. The support arm acts as a lever arm wherein the weight of the bow causes the connecting arm to move and the retaining arm to rotate from an open position to a closed position to secure the limb of the bow.