An apparatus comprising a substrate; and a platform elevated above the substrate and supported by curved flexures. An electro-mechanical operating device is located within the interior. A network operations center having a central control processor communicates with the processing communication satellite on the communications uplinks and the communications downlinks. A motor rotates the cutting wheel so that the tips are removed from the punches as they are rotated into the path of the wheel. t one against the other via their second faces that are self-adhesive, so as to form a flexible collar by uniting at least their facing free end zones The device further includes a rigid plate for constituting a support for fastening the device to the structure. The methods enable improved pharmacokinetic analysis during development and clinical use of antibody-based therapies as well as determination of diagnostic andor prognostic factors.