A topical anesthetic is provided containing about 3 wt % to 10 wt % tetracaine in a vehicle suitable for administration to the mucosa. A tunable optical filter filters an optical channel containing an optical signal and noise. For each nibble, a parallel to serial converter converts the nibble into serial data. A penetrating member sensor is coupled to the plurality of penetrating members. The memory cells in each block are arranged in rows. and a peak of Tm of 200 to 240\xb0 C.