This invention relates to novel cyclic malonamides having the formula :to their pharmaceutical compositions and to their methods of use. A focal plane is provided between the collector objective element and the camera element, and one or more aperture arrays may be situated in the focal plane to restrict the detector’s field of view of the specimen to the areas within the apertures. A cannula is straightened by inserting a straight stylet therethrough. The guiding visible light from the LED is guided to pass through the light guiding portion and arrives at the eye via the lens. The loop is advanced such that the first portion is located within the cooling region and the second portion is in frictional contact with the casing.