An illumination device is provided that reduces the amount of light leaked to improves illumination efficiency. The hydrazide starting compound is represented by Structural Formula : . The second distribution is a gradient of the component. The invention also relates to presymptomatic therapy of individuals who carry deleterious alleles of the HPC2 gene. In the chemical formula, the characters \u201cM\u201d, \u201cO\u201d, \u201cx\u201d and \u201cy\u201d indicate transition metal, oxygen, a transitional metal composition and an oxygen composition, respectively.