An optical frequency conversion method and device are provided by which a component other than a desired harmonic component can be eliminated with high precision and an output lightwave with the desired frequency component can be easily extracted even if the frequency of a modulation signal is changed. A top of the dielectric housing defines a plurality of locating slots. A positive capacitive element is disposed in the second insulator and is separated from the negative capacitive element by the second insulator. The user may interact with the system to modify the selected executable instructions, command code sets, and command keycommand code mappings. The probe may have an atraumatic tip with a ball formed at the leading edge. More specifically, the present invention relates to devices for sealing or closing an opening formed through biological tissue comprising a distal or outside margin or surface, and a proximal or inside margin or surface, and to apparatuses and methods for delivering such devices, to control bleeding.