It has now been found that compounds of the present invention as described in Benzodiazepine derivatives of Formula containing a carboxylic ester moiety and thereby capable of being inactivated by nonspecific tissue esterases in an organ-independent elimination mechanism and thereby providing a more predictable and reproducible pharmacodynamic profile. The ammonia andor ammonia products can be produced by compressing a gas mixture comprising nitrogen, hydrogen, methane, and argon to produce a compressed gas mixture having a pressure of from about 1,000 kPa to about 10,400 kPa. The container closure also includes a tamper band coupled to the flip-top caps and to the body until a consumer opens the flip-top caps for the first time.