Methods and apparatus are provided for calibrating a voltage controlled oscillator, such as an N-stage voltage controlled ring oscillator. The invention also relates to the pharmaceutical use thereof, for example in the treatment andor prevention of all forms of diabetes and related diseases, as well as to corresponding novel GLP-1 analogs. If an update is available, the update is copied from the server to the target client. Due to inconsistencies in, for example, the sphincterotome, anatomy, and endoscope manipulation, it is difficult to accurately and consistently position the sphincterotome for proper cannulation. 6, and wherein the second soft ferromagnetic layer pulls a magnetic field of the apparatus into the first soft ferromagnetic layer. Upon determining that the mobile station is not already registered, the website interacts with a user of the mobile station to obtain information from the user to register the mobile station and association thereof with the user at the website.