The present invention provides adjuvants, vaccines and therapies in which antigen presentation is enhanced through inhibition of negative immune regulators. The method includes storing segment frame icons representing segments of the video stream, the segment frame icons having a layout. It is then determined whether Sv+1 is located on the opposite side of the inflection point Sc from Sv. Evaluation information may then be obtained based on a variance of the value of the performance parameter at the plurality of locations. The method further includes marking, by the processor, instruction text of the subsequently fetched instruction to indicate that the subsequently fetched instruction is a previously executed tracked instruction based on the indication of the tracked instruction from the tracking array.