An intelligent vending system such as a pay telephone provides localremote diagnostics, fraud prevention, capability of facilitating local coin overtime operation, complete cash box accounting, and detailed reporting. Accordingly, a highlighting service includes a web portal with a web page providing users with a snippet of code, which, when inserted into an internet document, causes the internet document to display highlights from the highlighting service. The reservoir 51 includes a base 52, an upper end 50, and compressible walls 55. Disclosed are methods of making and using polypeptides and modified polypeptides as signals to localize therapeutics, experimental compounds, peptides, proteins andor other macromolecules to the endoplasmic reticulum of eukaryotic cells.