A process is presented for realizing buried microchannels in an integrated structure comprising a monocrystalline silicon substrate. The sensors may be mounted adjacent a test location exterior to the cassette. The invention still further provides isolated MID 9002 proteins, fusion proteins, antigenic peptides and anti-MID 9002 antibodies. A target portion of the resection surface may be identified based on, for example, fit and function testing of the joint with a trial arthroplasty prosthesis in place on the resection surface. A generally cylindrical-shaped second corer has an second-corer axis coaxial with the longitudinal drilling axis and a second coring end having a second coring diameter greater than the first coring diameter. The method comprises providing predetermined voice messages configured to ask questions to or to give instructions to an assisted individual, providing an algorithm configured to communicate with the assisted individual, and communicating at least one of the predetermined voice messages configured to ask questions to or to give instructions to the assisted individual.