A method, system and device for variable or dynamic classification of users, devices, computers, systems, or information are provided, including at least one of means for sensing one or more inputs, including at least one of an event, a parameter, and time; and means for generating a classification or policy for allowing access to information based on one or more of the sensed inputs. The method includes the steps of: forming a first bend in the wire loop at a predetermined portion of the wire loop; paying out a length of wire after step ; and forming a second bend in the wire loop at the predetermined portion after step. The corrected operation reaction force is generated in the accelerator pedal. The process provides a reliable and quantitative measure of the proportion of variant sequences within a DNA sample. Disorders treated andor prevented include Parkinson’s Disease.