One implementation provides a method of replying to a user electronic mail message sent from a user within a system that processes incoming user email messages and delivers responses to these incoming user email messages. Also provided are methods of improving yields in crops of useful plants in need of yield improvement by applying a herbicidally effective amount of one or more herbicides andor insecticides and yield-improving amount of isoxadifen or an ester thereof to the plants, parts of plants, plant seeds or the area under cultivation. First, for the treatment plan, a plurality of clinical and delivery goals are identified. The method can include additional steps or procedures, either separately or in various combinations. The top pulse is has the first identical-shape top pulses when the recording mark length is 3nT, the second identical-shape top pulses when the recording mark length is T, and the third identical-shape top pulses when the recording mark length is T.