The present invention is directed to methods of preparing nanoparticles of aqueous-insoluble compounds, particularly aqueous-insoluble bioactive compounds, and to compositions and medicaments obtained by these methods. Each of the detector modules has a plurality of element blocks permanently mounted on a module base. When the rotational rate of the front wheels exceeds the rotational rate of the rear wheels, the bidirectional clutch mechanism is engaged, a first rotor of the hydraulic pump which is operatively connected to the front wheels and a second rotor which is operatively connected to the rear wheels rotate relative to each other, and a rotational load is generated by a hydraulic circuit.