A microfluidic system with on-chip pumping which can be used for liquid chromatography and also electrospray ionization mass spectrometry and which provides improved efficiency, better integration with sensors, improved portability, reduced power consumption, and reduced cost. The cover plate includes a plate and a conductive layer. A control unit analyzes the sensed motion and the sensed oximetry signal, and filters out false alerts relating to a condition of the subject generated by the oximetry signal, based on correlation between the oximetry signal and an aspect of the motion signal. The power generation systems of the present invention may play a significant role in the modern aerospace and military industries. The control signal has a first voltage level during a first time period in which a state of the input signal changes, and has a second voltage level during a second time period in which a state of the input signal is constant. The controller determines whether an upset condition has occurred based on at least the temperature in the vicinity of the seal.