A low voltage differential signal driver includes first and second current sources, a first branch and a second branch. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising one or more analgesic agents. In another embodiment, a packaging machine includes an insertion section and a sealing station arranged downstream thereof in the working direction, in which at least one contact is provided for thermal transfer via heat conduction between a sealing plate and a heating plate for heating a lid foil.