Biological reagent carrier devices and methods are disclosed, which employ RFID techniques to associate information with biological reagents. An optical scanner is employed to create a thickness profile for the cornea. When the drive mechanism rotates the developer container in the developer feeding direction, while the torque limiter keeps the shutter stationary, the container body rotates through a predetermined angle to open the developer discharge port, and as the developer container continues to be rotated, the developer is fed through the developer discharge port. An instrumentation engine reads these instructions and injects the probe into the compiled application at the appropriate injection points. The nebulizer facilitates alignment with a mass spectrometer target, reduces sample and nebulizer gas leakage, is easy to assemble and disassemble, and operates over a wide range of sample flow rates.