Reovirus can be used to selectively remove ras-mediated neoplastic cells from a cellular composition. More particularly, a medical catheter is disclosed to detect the presence of blood vessels and to produce collateral openings or channels through the airway wall so that air is able to pass directly out of the lung tissue to facilitate both the exchange of oxygen ultimately into the blood andor to decompress hyper-inflated lungs. The actuator device can be incorporated into valve assembly to open and close the valve. The flat back portion has at least one aperture which is dimensioned and configured to permit a mounting bolt to pass there trough to bolt the flat back portion directly to the electric fixture so that the flat back portion contacts the wall.