The multi-level load balancing system receives requests for resources provided by any of a plurality of resource nodes. The transmitreceive switch comprises an impedance matching circuit and a voltage scaling circuit. Importantly, the spumavirus of the present invention or antibodies to the spumavirus can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies. For instance, rule files related to integrated circuit manufacturability may be selectively annotated to indicate portions thereof deserving of protection.