There are provided a new dosage regimens for the gamma secretase inhibitor 2,2-Dimethyl-N–6-oxo-6,7-dihydro-5H-dibenzob,dazepin-7-yl)-N–malonamide which maximizes anti-tumor activity while maintaining acceptable toxicity levels. The pellets may be introduced into water or other suitable oxidizer in a controlled rate to control the rate of reaction of the source material with the oxidizer, and thereby control the rate of formation of hydrogen. The pixels sampled from each two-dimensional color plane of the Bayer image are convolved with a coefficient kernel for each color. The density of crystal defects in a side surface produced by etching is smaller than the density of crystal defects in a side surface produced by dicing.