A semiconductor memory apparatus includes a bit line pair electrically connected to a memory cell and a bit line sense amplifier for detecting and amplifying voltage levels of the bit line pair. Methods for making such transgenic non-human animals, and using them to identify and characterize agents that affect conditions related to TIEG activity, such as cardiac hypertrophy and bone formation also are provided. Recombinant ssRNA is introduced into the strains and packaged to form rdsRNs de novo.