The present invention relates to modulators of ATP-Binding Cassette transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator, compositions thereof, and methods therewith. These diseases are characterized by aggregations of alpha-synuclein. A substrate having a first surface and a second surface opposite to each other is provided. A pair of lead wires is secured to the pair of terminal pads, and a lead cap assembly is disposed around the pair of lead wires and is secured to the protective cover. An exhaust unit for air is located opposite the front side and is positioned under the upper limiting wall.