A sheet substrate includes a plurality of substrate regions arranged in a matrix, an integrated circuit disposed in each of the substrate regions, and a first implementation electrode and a second implementation electrode disposed in each of the substrate regions and electrically connected to the integrated circuit. Also provided are methods for utilizing Histidine kinase polypeptides to screen for antibacterial compounds. This invention also provides methods for determining whether a subject is afflicted with Hepatocellular carcinoma. A thin oxide layer is formed in the trench and the buffer film layer is selectively etched to move the buffer film layer back from the corners of the trench. Resulting paper products formed from the processed fibers are also described as well as methods to make them. Manipulation of the handle toward the blade causes the pusher to push the strapping into engagement with the blade thereby cutting the strapping.