A signal transmitting circuit is provided for cutting off or outputting at least one driving signal for driving a designated light source. In particular, the present invention provides methods and systems for improved thermal treatment of target tissue, such as a pulmonary vein andor regions of the left atrium by reducing the resistive forces andor increased thermal energy experienced from blood flow exiting the pulmonary vein into the left atrium during treatment. The selected region may be applied to the image or to another image according to an image editing technique using an implement held or manipulated with the other hand, such as a stylus or cursor control device, or using one or more digits of the other hand. Alternatively, a return reflector such as an isosceles prism or a trapezoidal prism reflects and offsets returning beams so that the combined beam is offset from the input beam. The method further includes thermally treating the fibrous web so as to dry and bond the fibers of the fibrous web using the binder to form a bonded fibrous web nonwoven fabric and so as to sinter the thermoplastic polymer with a surface of the bonded fibrous web nonwoven fabric. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.