A system for planning and managing a software development project uses an extreme programming process and includes a graphical user interface for displaying graphs and for entering, displaying and modifying underlying planning data. In one exemplary method, a lower-dimension signature is generated for each of a plurality of data sets of a given dimension. One exemplary automated device for delivering a prescribed unit dose of medication to the syringe is in the form of an automated device having a fluid delivery device that is movable in at least one direction. The force sensor is located between adjacent surfaces of the body member and the transducer holder to sense a force applied between the surfaces. The second contact is formed on a rear side of the substrate, facing away from the semiconductor body. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.