The present invention provides an antifouling coating composition which comprises an organopolysiloxane having a crosslinkable reactive functional group, a crosslinking agent, a boric acid compound as a curing catalyst and a silicone oil having a number average molecular weight of 180 to 30,000 and a viscosity of 10 to 50,000 mPas and which is nontoxic and mild to the environment. The method includes the steps of providing a first radiation-sensitive material and applying a second radiation-sensitive material to the first radiation-sensitive material. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies andor inhibitory compounds as well as the use of such therapeutic compositions to regulate an immune response in an animal.