A piezoelectric element, comprising electrodes and a piezoelectric body formed between the electrodes. The outputs from the pair of parallel IIR filters are combined with the input signal to produce a reconstruction filter output in response to the input signal. Non-limiting examples of pharmaceutical compounds may include a nonsteroidal anti-inflammatory drug, a gastric irritating drug and combinations thereof. Optionally, an isolation region is formed between the boosted channel regions by applying a reduced voltage on one or more word lines between the selected word line and the word lines that receive the higher pass voltage. They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the activation of MC-4R, such as obesity, diabetes, sexual dysfunction, including erectile dysfunction and female sexual dysfunction.