Methods and compositions for modulating the immune system of animals by activating macrophages to release cytokines and down-regulating their sensitivity to bacterial endotoxin and to conversion to cytotoxic phenotypes by the administration of high doses of stress response factors released by stressed bacteria. These inventive techniques are ideally suited for traffic monitoring. A first dielectric layer is formed over the first active area and the field region and a second dielectric layer is formed over the second active area and the portion of the first dielectric layer over the field region. The light source emits the illuminating light. A coated product such as confectioneries such as chewing gum, medicines and medicinal tablets wherein the product is coated with a coating composition comprising hydrogenated indigestible starch syrup as a binding agent. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.