A cryopump includes a second-stage cryopanel, a radiation shield that surrounds the second-stage cryopanel and has a shield opening, and a first-stage cryopanel provided in the shield opening. The oral hygiene implement includes a housing; a movably mounted functional element; a fixation element that is secured at the housing and that essentially locks the functional element at the housing; and an axle that is supported by the fixation element. The predictive routing scheme takes advantage of the predictable qualities of a LEO constellation, such as constant satellite footprint, constant satellite velocity, and predictable satellite trajectory. An amplification product detection complex and method of forming the same are also provided.