Biimidazole diamide compounds that are useful for binding anions such as sulfate are described, along with the use thereof for purposes such as extracting anions from a waste stream andor detecting anions. The system includes both a section mode and a pressure mode. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The first region of the diode and the third region of the programmable structure are electrically connected. The carrier structure which includes the common die can form a complete SoC by connecting to an expansive die through the custom interface.