Vapor compression air conditioning systems are provided with a flow restrictor for transferring working fluid to and from at least one of the compressor low pressure inlet conduit and compressor high pressure outlet conduit to provide for accurate charge adjustment to achieve predetermined fluid sub-cooling. The floatation material is a closed cell foam material, the flexible mesh is a nylon mesh, and the bonding material is a polyvinyl chloride paint. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Thus, the compounds of the invention may be used as anti-tumor agents, or for the treatment of cancer.