A self-cleaning plasticizing venting and extruding apparatus by co-rotating non-twin multi-screws and a method thereof are provided, said apparatus comprises a screw mechanism, barrel, feeding port, venting port, discharging port, and driving mechanism. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2. As part of the relative risk calculation, the tool uses a simulation and gaming environment in which artificially intelligent actors interact with the environment to determine susceptibility to the undesired event. The bracket is further provided with a compression means for compressing a breast during an imaging procedure.