A system for transfer of cryogenic fluids between an onshore storage tank and offshore loadingunloading station requires an insulated transfer pipe that is inclined with lower elevations toward the offshore station. Even when an inertia is varied during an operation or a viscous friction is high, the inertia or a viscous friction coefficient can be identified by a control parameter adjusting unit for performing a calculation on the basis of a torque command Tref and the speed Vfb of a motor. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation. The laser beam, after adjusting to a next predetermined angle and adjacent a previous row of trepan cuts, is pulsed to create a plurality of rows of trepan cuts wherein each cut in the previous row of trepan cuts is connected to a cut in said subsequent row of trepan cuts.