Compounds having the formula I wherein A, Z, R1a, R1b, R2, R3, R4, R5, R6, R7, R9, R10, Ra, Rb and n are as defined herein are inhibitors of PAK1. A monitor node is used to measure latency in a computer network or in a computing device by time stamping signal messages sent from nodes in the computer network andor tasks in a particular node or device. Reversible resistance changes are induced in the device under applied electrical pulses. Derived device measures are generated to provide derivative physiometry based on the collected device measures.