Provided is a dry powder for inhalation formulation comprising salmeterol xinafoate, fluticasone propionate and tiotropium bromide, as pharmaceutically active ingredients, and a carrier, and an inhalation formulation comprising same. Also described is a corresponding manufacturing method. The system includes a disposable cassette with first and second valve chambers and a control unit into which the cassette is capable of being received. A user interface is operable for a user to query the categories in the directory shell. The handle includes a mechanism for coupling the shaft to the handle and releasing the shaft from the handle.