Disclosed are several methods, apparatus, and a system for providing hypertensionhigh blood pressure symptom relief through a laser based medical instrument. Preferably, the antagonist is administered repeatedly over time by subcutaneous injection. The workpieces may be similarly shaped, e. A microelectronic topography resulting from one or more of the methods includes a film formed in contact with a structure having a bulk concentration of a first element. A tapered portion defined as a decrease in inner diameter from the first inner diameter to the second inner diameter between the proximal and distal ends, the tapered portion configured to prevent cavitation of the blood within the cannula.