An osteotome includes a penetration tool which is to be driven into a bone and a separate, elongate driving tool for use in driving the penetration tool into the bone. The RF switch includes switching and shunting transistor groupings to alternatively couple RF input signals to a common RF node, each controlled by a switching control voltage or its inverse, which are approximately symmetrical about ground. A linkage is connected with the load roller. This application additionally provides for use of laquinimod in the manufacture of a medicament for increasing BDNF serum level in a human subject.