Analytical reagents and mass spectrometry-based methods using these reagents for the rapid, and quantitative analysis of proteins or protein function in mixtures of proteins. The first magnetic core includes a base having a first edge; a first contacting structure disposed on the base; and a second contacting structure disposed on the base, wherein a distance between an inner surface of the first contacting structure and the first edge is larger than a distance between an inner surface of the second contacting structure and the first edge. In the present invention, the engagement portions may also be formed on the substrate and the light transparent cover so that the alignment can be undertaken easily. The controller 60 determines user preferences and changes a display of the electronic program guide in response to the user preferences. The beam is operable to rotate about the axle on the plate and reposition the subchondral fragment of bone. The active material in accordance with the present invention contains a crystallite of LiMnPO4, the crystallite having a size of 20 to 93 nm in a direction perpendicular to a plane thereof.