This invention is directed to aromatic sulfone hydroxamic acids and salts thereof that, inter alia, inhibit matrix metalloproteinase activity andor aggrecanase activity. In an example, an apparatus is configured to transvascularly stimulate a nerve trunk through a blood vessel. A control unit is coupled to the second drive means to adjust a circumferential speed of the inking rollers with respect to a circumferential speed of the letterpress form cylinder so as to adjust deposition of ink by the inking device on the letterpress form cylinder.