An MRI compatible electrode circuit construct is provided. The method utilizes a dispenser comprising an elongate dispenser body having a proximal end and a tip at a distal end through which a liquid medicament is dispensed. Also, the second electrode portion 13 and the fourth electrode portion 15b constituting the low impedance portion are substantially equal in area and the third electrode portion and the fourth electrode portion are formed in one piece, so that energy propagation efficiency can be increased. Signal to noise ratios are obtained for each run of an orthogonal array in order to identify important subsets. The invention also provides methods of making the bifunctional heterocyclic compounds, and methods of using such compounds as anti-infective, anti-proliferative agents, anti-inflammatory, andor prokinetic agents. The engine includes a first cylinder having a first piston and a second cylinder having a second piston, a first crankshaft operably connected to the first piston and a second crankshaft operably connected to the second piston.